医薬論文の構成・表現の勉強001

用語と表現、文章例

enhance（増やす、高める）

LX4211 enhanced urinary glucose excretion by inhibiting SGLT2-mediated renal glucose reabsorption.

mediated trends

LX4211 also mediated trends for lower weight, lower blood pressure, and higher glucagon-like peptide-1 levels.

without evidence of

LX4211 was well tolerated without evidence of increased gastrointestinal side effects.

underscore（強調する、下線を引く）、precipitating（突然もたらされる）

These concerns underscore the need to develop new agents that safely and effectively treat hyperglycemia without precipitating hypoglycemia in patients with diabetes.

without evidence of

LX4211 was well tolerated without evidence of increased gastrointestinal side effects.

appeared balanced

The treatment groups appeared balanced in terms of baseline demographics and disease characteristics.

spanning（橋をかけている、またがる）

In the LX4211-treated groups, the amount of glucose excreted in the first 8 h was comparable to the amount of glucose excreted in the period spanning 8-24 h.

alter（変更する）

Both tablet formulations were also associated with an increase in active GLP-1 between 0 and 13 h, whereas glucagon values were not altered.

hypothesize that

We therefore hypothesize that partial inhibition of intestinal SGLT1 by LX4211 results in delayed glucose uptake, which triggers the release of …

established diagnosis

… and included both male and female patients, 38?64 years of age and with an established diagnosis of T2DM, either naive to therapy or not well controlled on metformin　monotherapy.

参照した論文

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial

PMCID: PMC3400893 [Free PMC Article]

開発相：phase 1

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